Contextual Memory Formation Npas 4 Regulates a Transcriptional Program

نویسنده

  • Kartik Ramamoorthi
چکیده

This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): December 22, 2011 www.sciencemag.org (this infomation is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/334/6063/1669.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2011/12/21/334.6063.1669.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/334/6063/1669.full.html#ref-list-1 , 15 of which can be accessed free: cites 53 articles This article

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Npas4 regulates a transcriptional program in CA3 required for contextual memory formation.

The rapid encoding of contextual memory requires the CA3 region of the hippocampus, but the necessary genetic pathways remain unclear. We found that the activity-dependent transcription factor Npas4 regulates a transcriptional program in CA3 that is required for contextual memory formation. Npas4 was specifically expressed in CA3 after contextual learning. Global knockout or selective deletion ...

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Kartik Ramamoorthi Contextual Memory Formation Npas 4 Regulates a Transcriptional Program

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Neuronal PAS domain protein 4 ( Npas 4 ) regulates neurite outgrowth and phosphorylation of synapsin I

Background: Npas4 is involved in memory formation, but its roles in neuronal function remain to be fully elucidated. Results: Npas4 increased Cdk5-dependent phosphorylation of synapsin I that was associated with neurite elongation. Conclusion: Npas4 induced Cdk5-dependent phosphorylation of synapsin I to facilitate neurite outgrowth. Significance: Npas4 plays an important role in the structural...

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Covalent Modification of DNA Regulates Memory Formation

DNA methylation is a covalent chemical modification of DNA catalyzed by DNA methyltransferases (DNMTs). DNA methylation is associated with transcriptional silencing and has been studied extensively as a lifelong molecular information storage mechanism put in place during development. Here we report that DNMT gene expression is upregulated in the adult rat hippocampus following contextual fear c...

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It has been established that regulation of chromatin structure through post-translational modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an important early step in the induction of synaptic plasticity and formation of long-term memory. In this study, we investigated the contribution of another histone modification, histone methylation, to memory forma...

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تاریخ انتشار 2011